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1 The increasing burden of obesity during adolescence is of particular concern because excess weight gained during this critical developmental period frequently persists into adulthood, substantially increasing long-term morbidity and mortality

Steven et al (157) demonstrated that a 6-month intervention with a very low-calorie diet led to a decrease in fasting blood glucose levels in patients with T2DM

IL-1 and IL-6 are key pro-inflammatory cytokines that trigger local inflammatory responses and tissue damage, while IL-4 and IL-10 are major anti-inflammatory cytokines that inhibit the production of pro-inflammatory factors and promote the resolution of inflammation (44)