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Sheer and colleagues reviewed electronic health record data from 26,408 adults treated in the OneFlorida+ network from 2014 to 2024, covering 14 healthcare organizations across Florida, Georgia, and Alabama

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Oxidative modifications of various proteins in many different sub-cellular organelles (e.g., mitochondria, ER, etc) would promote their inactivation, resulting in mitochondrial dysfunction and ER stress

Shaking the vial can introduce bacteria or other contaminants into the water, so it should be handled gently