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Increased levels of type 1 interferon in a type 1 diabetic mouse model induce the elimination of B cells from the periphery apoptosis and increase of their retention in the spleen

This will allow protection against cancerous metabolic tissue reprogramming pathways, chromosome stability, provide normal stem cell differentiation and proliferation, ensure physiologic cellular composition balances in target the tissue, and protect the immune system from suppression or hyper-activation

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While lactylation enhances M1 polarization in the early stages of inflammation, sustained lactate accumulation during M1 polarization induces histone H3 lactylation at lysine 18