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Notably, newborn infants are at risk of severe toxicity (as discussed in Contraindications), but in adults and older children, the small benzyl alcohol dose is very well tolerated

The presence of Nrf2 and its inhibitor Keap1 in plasma is associated with damaged vascular endothelial cell-, macrophage-and other cell-associated leakage secondary to the loss of cell membrane integrity due to lipid peroxidation following chronic inflammation and oxidative stress (Kasprzak et al., 2020), and Nrf2 and Keap1 in circulation are markers of severe inflammation and oxidative stress (Tu et al., 2019)

Phosphate buffers are often preferred for this route because they can be used in slightly higher concentrations (typically up to 50 mM) without causing significant discomfort

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