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By evaluating the data from RCTs in RMS patients, significant differences in the percentage brain volume change (PBVC) (SIENA software) from week 24 to week 96 between the ocrelizumab- and the IFN -1a group were observed in the OPERA I (PBVC = 0.57% vs 0.74%, 22.8% difference, p = 0.004), but not in the OPERA II (PBVC = 0.64% vs 0.75%, 14.9% difference, p = 0.09) [2]

This plays a vital role in nerve development and signal transmission

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Despite the promising results, there remains a need for more comprehensive studies that critically evaluate the underlying mechanisms and potential clinical implications