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Similarly, GLP-1RAs exert the potential protection against inflammatory responses in T1DM through decreasing IFN- secretion and downregulating PD-1 expression in T cells by attenuating the Janus kinase (JAK)-STAT pathway [146, 147]

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Request comprehensive metabolic panels every 3-6 months that include: ALT and AST: Primary markers of liver cell damage GGT (gamma-glutamyl transferase): Sensitive marker for alcohol-related liver stress Bilirubin: Measures livers ability to process waste products Albumin: Indicates livers synthetic function Elevated GGT combined with normal or slightly elevated ALT/AST is a pattern that suggests alcohol-related liver stress even when other markers look acceptable

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Why Muscle Loss Can Happen on GLP-1s Several factors can contribute to lean mass loss during GLP-1induced weight loss: reduced total calorie intake, inadequate protein intake, and lack of resistance training

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