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In T2D models, GPER activation has been shown to improve insulin resistance and lower blood glucose levels, suggesting its potential therapeutic value in regulating metabolism [4]

More recent studies have reported the presence of a constitutive adult neurogenesis in other brain regions including the striatum, amygdala, olfactory cortex [12], and the hypothalamus [13] (see Box 1)

Thus, methods are still being sought that can improve the situation, and MEL, due to its pleiotropic properties, may play a vital role in this regard

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