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While the relatively modest plasma glucose increases in FATP2-KO db/db mice compared with WT mice could result in some glucagon-stimulated insulin release, synthesis of the data from all metabolic studies most strongly indicate that the predominant FATP2 gene deletion effect on glycemia was the paracrine effect of GLP-1 secretion by cells

In patients with T2DM, extended treatment with insulin can significantly improve endothelial-dependent vasodilation (113)

In the PPI network, the larger and darker the color of the target node in the network graph, the more important the target in the network

A previous metabolic assessment of RAMP KO mice indicated a specific contribution of RAMPs to eating and metabolic behaviours, with AMY 1 R identified as a key factor in regulating fat metabolism