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The 2025 Brunel study is valuable because it used rigorous methodology and represented true independent replication

4 keeps eNOS in a coupled state, in which it synthesizes NO rather than harmful superoxide (Crabtree et al., 2009b)

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The clinical trial observed over 7,000 adults with type 2 diabetes at high risk for cardiovascular (heart) problems taking Jardiance in addition to the "standard of care" for heart disease risk reduction (e.g., statins, blood pressure lowering drugs, aspirin, etc.) and diabetes care (most participants were taking other diabetes medications as well)