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Kojic acid typically shows initial results in 2-4 weeks, glutathione in 4-8 weeks, and alpha arbutin in 6-12 weeks

Total RNA was extracted from the hippocampal tissues using an RNA simple Total RNA kit (Tiangen Biotech Co., Ltd.), and the FastKing gDNA Dispelling RT SuperMix kit (Tiangen Biotech Co., Ltd.) was used to synthesize cDNA

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