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up-regulating brain-derived neurotrophic factor [BDNF], nerve growth factor [NGF], neurotrophin [NT]-3 and NT-4/5 expression, etc.), attenuating blood-brain barrier (BBB) disruption, improving mitochondrial function, maintaining calcium ion homeostasis (e.g

Additional harmful metabolites produced by dysbiotic microbiota, such as p-cresol sulfate, further impair BBB integrity by activating signaling pathways that degrade tight junction proteins [259]

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27 However, contrary to preclinical findings, human studies indicate that weight loss induced by GLP-1 RAs is primarily due to reduced energy intake rather than increased energy expenditure