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Possibly, this toxicity, in addition to lower esophageal sphincter and pyloric sphincter failure, involves sole NSAIDs-gastric ulcers, presenting with aspirin (and thereby, aspirin was used intragastrically) (14) and ibuprofen (10), as well as with those agents combining gastric and small intestine ulcers (i.e., diclofenac (9, 11))

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Nature 433:769773 Lindpaintner K (2002) The impact of pharmacogenetics and pharmacogenomics on drug discovery

Front Pead 10:855943 Ismail IT, Showalter MR, Fiehn O (2019) Inborn errors metabolism era untargeted metabolomics Lipidom Metabolites 9(10):242 Ferreira CR et al (2019) A proposed nosology of inborn errors of metabolism