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Significant barriers still exist despite established safety profiles, such as high costs that restrict access worldwide, a lack of predictive biomarkers for treatment response, a lack of knowledge about the mechanistics of gut microbiota interactions, and an incomplete understanding of long-term safety, particularly with regard to thyroid and pancreatic effects

yet these agents may favor an increase of lean mass and mimic an energy deprivation state with increased ketogenesis (i.e., BHB) through increased circulating GH levels ( Figure 1 )

However, insurance typically does not cover compounded medications

Be persistent