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Weight loss continues progressively for 12 to 18 months before plateauing, with maximal effects requiring sustained treatment at maintenance doses

Additionally, other potential confounders, such as factors affecting the physician's prescription preferences, were not accounted for and we cannot rule out confounding by indication

Importantly, their influence extends to skeletal muscle, where GLP-1 RAs promote glucose uptake via the AMP-activated protein kinase pathway, increase vascular blood flow, and mitigate glucotoxicity, thereby supporting muscle protein synthesis and inhibiting catabolic pathways [14, 15]

Frequently Asked Questions Are GLP-1 patches available on the NHS