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Sulforaphane also activates antioxidant pathways, such as Nrf2/ARE pathways which regulate glutathione

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3 Transmembrane transport of Mn and systemic regulation In this review, we separate transmembrane transport at the cell-level uptake/efflux across polarized membranes (e.g., enterocytes, hepatocytes, brain endothelium), and systemic regulation at organ-level fluxes that determine how Mn moves among the intestine, liver, blood, and brain

Ferroptosis plays an important regulatory role in the occurrence and development of many diseases, such as tumors, neurological diseases, acute kidney injury, ischemia/reperfusion, etc