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CYP3A4 is a metabolizing enzyme for almost 50% of drugs, and is found in the liver and small intestinal epithelial cells
Key Takeaway: If you experience a worsening of "typical" thyroid symptoms after starting a GLP-1, it is usually a sign that your thyroid hormone requirements have changed due to weight loss or absorption shifts
Unlike injectable GLP-1 medications, Orforglipron is taken orally and has shown encouraging early results
Influences intracellular anabolic signaling pathways: Elevated GH and IGF-1 levels activate intracellular pathways responsible for protein assembly and cellular growth
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