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So low levels of vitamin B12 could be helping cause your fatigue

Diagnosis typically involves blood tests including full blood count (showing macrocytosis), anti-intrinsic factor antibodies (which are specific for pernicious anaemia), and sometimes anti-parietal cell antibodies

It affects an enzyme called NNMT, which acts like a metabolic leakdraining away essential components: NAD (crucial for energy production) SAM (the universal methyl donor) This is significant, especially since NNMT is upregulated in conditions such as obesity, diabetes, Alzheimers, Parkinsons, and aging

Laboratory animals were housed in polycarbonate (PC) cages under conventional laboratory conditions at 2024 C, relative humidity of 4070% and noise level 60 dB