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Moreover, since at the time of diagnosis, 50% of patients presents metastases, 29% local/regional spread, and only 3% pancreatic carcinoma in situ, less than 15% of patients are eligible for surgical resection, compromising research efforts for inadequate number of available human samples [9,10,11, 13, 14]
These data showed that subchronic (7 to 14 days) exendin-4 or liraglutide administration in rodents resulted in hyperactivation of the HPA, disruption of glucocorticoid circadian secretion, hypertrophy of the adrenal gland, and dysregulation of pituitary-adrenal stress responses [77]
The role of nutrition in the etiology of inflammatory bowel disease
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