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Furthermore, studies such as the STEP-HFpEF trial with GLP-1 receptor agonists have shown optimized exercise capacity and reduced heart failure symptoms in patients

Indication-specific advantages: Glucagon co-agonists such as survodutide, mazdutide, and retatrutide may have superior hepatic effects in MASH and MASLD because glucagon acts directly on liver lipid metabolism

In practice combination therapies can deliver stronger glycemic control, more noticeable weight reduction, and a better patient response than using a single medication on its own, even when the goal seems the same