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Most patients with IC/BPS report a history of urinary tract infection and have received several courses of antibiotics based on their symptoms, not on positive urine cultures

Notably, pathological remodeling in these diseases could be attenuated or prevented not only by mast cell stabilizers or in mast cell deficient animals [89, 90], but alsoat least in vitroby DNase treatment [91, 92], suggesting a potential pathogenic contribution of MCETs