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However, in a Y-79 human retinoblastoma xenograft nude mouse model (0.05 g per mouse, intraperitoneal injection, 5 times weekly for 5 weeks), the drug caused 90% mortality, weight loss, lethargy, and mild bilateral renal tubular calcification, suggesting significantly increased systemic and nephrotoxicity risks under specific high-dose or long-term administration conditions (Sabet et al., 1999)

Alcohol can interfere with the absorption of vitamin B12, reducing the effectiveness of the treatment

Interestingly, AMS, DADS, DAS, and SAC show the same Zn(II) dissociation as the control, indicating no modification under the conditions used