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The reason for this is that they start to develop their internal day-night (circadian) rhythm that favours sleep at night and being more awake during the day

To regulate and guide the research and evaluation of nanomedicine, the Center for Drug Evaluation (CDE) of the China National Medical Products Administration formulated the Technical Guidelines for Nanomedicines Non-Clinical Safety Evaluation Research (Trial), which was issued in August 2021 (Center for Drug Evaluation of Chinese National Medical Products Administration, 2021)

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