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Back Majzoub, JA, Kronenberg, HM, Potts, JT, et al (10 Aug 1979) 'Identification and cell-free translation of mRNA coding for a pre- cursor of parathyroid secretory protein', The Journal of Biological Chemistry , 254/15, 7449-55

This level of weight loss is considered significant and exceeds that typically achieved with previous generations of weight-loss drugs

Dose Escalation Structure Phase Weekly Dose Weeks 14 1 mg Weeks 58 2 mg Weeks 912 4 mg Maintenance (research range) 68 mg Clinical trials have evaluated doses up to 12 mg once weekly with gradual titration

Studies in obese rodents fed high-fat diets for extended periods show that diminished carnitine reserves in skeletal muscle are accompanied by marked perturbations in mitochondrial fuel metabolism, including reduced complete fatty acid oxidation, elevated incomplete -oxidation, and impaired substrate switching from fatty acid to pyruvate oxidation