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It mimics the action of ghrelin, the hunger hormone, by binding to the ghrelin receptor (GHS-R1a) in the hypothalamus

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Molecular mechanisms of ferroptosis Erastin and RSL3, two distinct small molecule inhibitors lacking structural similarities, were previously identified for their selective lethal impact on oncogenic RAS mutant cell lines

In the SELECT trial, semaglutide reduced major adverse cardiovascular events in patients with overweight or obesity and established atherosclerotic cardiovascular disease without diabetes [16]