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Un aspecto importante es que el GLP-1 endgeno tiene una vida media muy corta (aproximadamente 1-2 minutos) porque es rpidamente degradado por la enzima dipeptidil peptidasa-4 (DPP-4), lo que limita sus efectos fisiolgicos naturales

GLP-1 agonists bind to GLP-1 receptors on pancreatic beta cells, stimulating insulin secretion in a glucose-dependent mannermeaning they only promote insulin release when blood glucose levels are elevated

Like all prescription drugs, GLP-1s can cause side effects

This effect has limited the use and production of GIP analogues as they may potentiate the diabetogenic glucagon effect through augmented gluconeogenesis and glycogenolysis