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When both rapid auditory processing and tonic inhibition are impaired, some studies have reported a paradoxical decrease in central gain in certain patient subgroups, particularly those without comorbid hyperacusis (Chen et al., 2021

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BH4 pairs with dihydrobiopterin (BH2) to form a redox cycle that scavenges endogenous oxidative radicals, protects lipid membranes, and inhibits ferroptosis [68]