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Future research should aim to validate our findings in larger and more diverse pediatric cohorts, and to explore potential differences in subgroups with varying severity of GHD or higher levels of injection-related anxiety

In the more conservative estimate, maximum Part D spending could see an additional $34 billion per year, the researchers found, while spending in the more liberal estimate was calculated to reach an added $145 billion per year

Advantages: - Once-weekly convenience for most formulas - Well-studied efficacy and safety data - More consistent absorption - Compounded versions available at lower cost Considerations: - Requires self-injection or provider administration - Needles can be a barrier for some patients Oral semaglutide (Rybelsus) is currently the only FDA-approved oral GLP-1 medication

Safety Profile The safety data from clinical trials reveal a characteristic side effect profile: Common Side Effects: Serious Concerns: Blood pressure effects led to discontinuation of intranasal development in 2007 after transient blood pressure increases were observed