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Other Symptoms of B12 Deficiency Besides headaches, a B12 deficiency can cause: Fatigue and weakness Dizziness or lightheadedness Tingling or numbness in hands and feet (peripheral neuropathy) Memory problems or confusion Mood changes (depression, irritability) Pale or yellowish skin Vision disturbances If you experience these symptoms along with frequent headaches, consult a doctor for a blood test

J., Dantzer, B., Delehanty, B., Palme, R