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In addition, high levels of it can end up accumulating inside the brain causing irreversible damage in areas such as the basal ganglia, producing kernicterus or bilirubin encephalopathy (1, 2)

It is prescribed based on medical necessity and individualized care when customized dosing is needed to improve tolerability or support gradual titration

This analysis was a prespecified secondary analysis of the SUMMIT Trial, which showed that the long-acting glucose-dependent insulinotropic polypeptide receptor and glucagon-like peptide-1 receptor agonist tirzepatide decreased risk of cardiovascular death or worsening heart failure (HF) in patients with (HFpEF). As it pertains to sex, the investigators noted that women outnumber men with HFpEF, and there are sexual dimorphisms in the relationships between body fat and pathophysiology in HFpEF that could influence response to tirzepatide. In the SUMMIT trial, the investigators analyzed 731 patients (338 men, 393 women) with class II-IV HFpEF and BMI of 30 kg/m 2 or greater