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In addition, the exosome of CAFs, LINC01614, has been demonstrated to directly interact with ANXA2 and p65, thereby promoting NF-B activation

Animal studies are also included in this table and clearly identified as such

Feeding mice with the KD resulted in a noteworthy decrease in the expression of immune inhibitory receptors (PD-1 and CTLA-4) on CD8 + TILs, as well as a reduction in the expression of inhibitory ligands (CD86 and PD-L1) on cancer cells

KARs especially those containing Glutamate receptor ionotropic kainate 4 and 5 (GluK4/GluK5), mediate oligodendrocyte and neuronal vulnerability (Lerma and Marques, 2013)