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Only 26% of patients had been titrated to goal by the primary endpoint at week 30, at which time the mean daily insulin dose was 29 U per day

By binding to opiate receptors, tramadol can block pain and also cause a person to feel more relaxed and often happier

PMID: 33521019

Risks appear particularly elevated in individuals with comorbid depression or BED, where long-term outcomesespecially following discontinuation of pharmacotherapyremain insufficiently studied [143]