GLP-1 drugs also slow down how fast the stomach empties, reduce appetite, and lead to weight loss
Insulin levels were quantified in media from cultures of WT and Glp-1r KO mouse (C57/Bl6 background) islets treated with GLP-1(7-36), GIP(1-42), GLP-1(9-36), LSN3160440, or GLP-1(9-36) plus LSN3160440 in the presence of 11.2 mM glucose ( a ) or 2.8 mM glucose ( b )
Diabetologia 55:26672676 Xu G, Stoffers DA, Habener JF, Bonner-Weir S (1999) Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats
Coverage is often difficult if you don't have diabetes or meet obesity criteria, since these drugs aren't yet FDA-approved specifically for RA