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Temporary changes may occur: During intense physical exertion During immune activation As part of normal gutimmune communication An expert consensus paper by Bischoff et al., published in BMC Gastroenterology (2014) , emphasized that intestinal permeability should be viewed as a functional biological state rather than a disease entity

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It is used in the treatment of painful nerve disease called peripheral neuropathy,It also helps to treat anemia, fatigue, and numbness or tingling in hands and feet and muscle weakness