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414 Together, these effects contribute to the protection of dopaminergic neurons (source)

Phase 2 trial data showed a mean body weight reduction of approximately 24% at the 12 mg weekly maintenance dose over 48 weeks

Decrease in Serum Bicarbonate In a trial of concomitant therapy of dapagliflozin 10 mg with exenatide extended release (on a background of metformin HCl) in adults, four patients (1.7%) on concomitant therapy had a serum bicarbonate value of less than or equal to 13 mEq/L compared to one each (0.4%) in the dapagliflozin and exenatide extended release treatment groups [see Warning and Precautions (5.2)]