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Because of this, semaglutide should not be used in people with: A personal or family history of medullary thyroid carcinoma (MTC) MEN2 (Multiple Endocrine Neoplasia syndrome type 2) Other serious risks that have been reported with GLP-1 receptor agonists include pancreatitis, gallbladder disease, potential kidney problems, and (in some regulatory guidance) the need to monitor for changes in mood or suicidal thoughts

For appropriate patients, GLP-1 therapy may be a helpful tool, but it should not replace medical evaluation, nutrition, strength preservation, and follow-up care

During the hypoglycemic period after a meal in GDH-HI patients, the plasma insulin concentrations may be reduced, indicating that high insulin levels are not the only cause of hypoglycemia in GDH-HI patients

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