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Most spermidine supplement doses are around 25mg or less.51 Glutathione Like spermidine, glutathione is generally very safe at clinically relevant doses, with toxicity requiring an intake higher than 30g/day.52 Thats significantly more than the 250-1,000mg typically used in successful studies.53 Ginseng In a significant review looking at 44 randomized controlled trials of ginseng in humans with a wide range of doses, a majority of studies reported no adverse effects.54 The most abundant adverse effects within the combined participant pool were hot flashes, insomnia, and GI upset, with about twice as many of those effects occurring in treatment groups compared to placebo

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Clinical trials in NASH patients have demonstrated histological improvement with semaglutide treatment [8]