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We do know that GLP-1s have powerful anti-inflammatory effects, but we dont yet fully understand: Long-term impact on Lipedema fat Effect on fibrosis Impact on lymphatic health Interaction with Lipedema-specific metabolic patterns For now, the approach must be personalised, cautious, and monitored

These include extended-release formulations, combination therapies, and targeted molecular treatments designed to improve efficacy, minimize side effects, and enhance patient adherence

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Some patients may experience recurrence of the fissure once the Botox wears off, in which case a more permanent solution, such as LIS, may be necessary