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Preventing or delaying the onset of dementia and depression should therefore be a world public health priority [29,30,32]

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90,91 However, gene editing approaches remain effective in treating inherent mtDNA mutations, while the ROS-induced sporadic and clonally expanding mtDNA mutations observed in -thalassemia and related hemoglobinopathies present challenges for current gene editing therapeutic strategies

Abstract Carnitine is essential for mitochondrial fatty acid -oxidation and redox homeostasis, and mounting evidence shows that carnitine metabolism is profoundly perturbed in diabetic kidney disease (DKD)