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Most users settle into a preference within the first few weeks

10.1016/j.celrep.2021.109960 131 XuB.WangZ.LiG.LiB.LinH.ZhengR.et al (2006)

When taken as a pill, however, the drug must first pass through the stomach and intestines, where some of its active ingredient is broken down by digestive enzymes before it can be absorbed through the gut lining and into the blood

However, clinical evidence shows this interaction is generally minor because amoxicillin absorption happens efficiently even with delayed gastric emptying