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doi: 10.3389/FMICB.2018.02928 137 PinoP.PellegrinoG.RonchettiS.MolleaC.BoscoF.OnidaB
Enzyme-activated prodrugs and their release mechanisms for the treatment of cancer
95% CI, 0.820.92).[21] Another study revealed that semaglutide and tirzepatide were promising potential therapies in patients with obesity and comorbid alcohol use disorder,[56, 57] and dulaglutide use for smoking cessation did not improve tobacco abstinence but did reduce alcohol consumption.[58, 59] Studies of exenatide reported improved smoking cessation outcomes, though no benefit was observed for cocaine or alcohol use.[6062] A comparative study found semaglutide associated with a significantly lower hazard ratio for nicotine use versus sitagliptin, empagliflozin, and glipizide.[63] Additional GLP-1RA uses Emerging off-label indications for GLP-1RAs continue to be identified, with future research potentially establishing a basis for their extended therapeutic application in a range of medical conditions
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