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Monitoring focuses on IGF-1 trends, glucose handling, lipids, and fluid-retention symptoms

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The hepatic artery and the portal vein from the intestine merge at one end of the sinusoid in the periportal region of the lobule and flow into the central vein at the other end of the sinusoid in the pericentral region of the lobule (Abdel-Misih and Bloomston, 2010)

Based on the observation that Keap1 functions as a homodimer, the heterozygous missense mutation generates three types of Keap1 dimers, i.e., wild-type homodimer, wild-type-mutant heterodimer, and mutant homodimer at a ratio of 1:2:1