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More serious but rare complications include pancreatitis, gallbladder disease, and worsening of diabetic retinopathy (particularly with rapid improvement in blood glucose)

Research in diabetes and weight loss populations shows that patients on GLP-1 therapy experience a measurable shift in fluid intake patterns, often consuming 1520% less water than baseline without realizing it

[DOI] [PubMed] [Google Scholar] 29.Vecchiet L, Di Lisa F, Pieralisi G, Ripari P, Menabo R, Giamberardino MA, Siliprandi N

Superior weight loss with onceweekly semaglutide versus other glucagonlike peptide1 receptor agonists is independent of gastrointestinal adverse events