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Retatrutide, a not endogenously occurring peptide, stimulated the glucagon receptor (GCGR), the glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR), and the glucagon-like peptide-1 receptor (GLP-1R) in cell cultures

These findings provide further evidence for the impact of GLP-1RAs on osteoclastic bone resorption

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Because retatrutide engages three metabolic receptors, the body experiences a strong shift in energy balance, appetite signaling, and gastric speed, especially during early dose escalation