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Abbas T, Faivre E, Hlscher C (2009 Dec 14) Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: interaction between type 2 diabetes and Alzheimers disease
A contribution of NTS astrocytes to the appetite suppression caused by acute GLP-1R agonists also seems possible from evidence showing (1) expression of GLP-1Rs in this cell type, (2) functional responses of astrocytes to exendin-4 and liraglutide, and (3) negation of appetite suppression from administration of exendin-4 into the NTS when astrocyte metabolism is selectively inhibited in this region [56]
High), non-diabetic individuals treated with semaglutide (Class IVIII
Dual therapy may be considered if the A1C level is 9% or greater at initial presentation
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