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These include: Pre-existing constipation or slow transit constipation Inadequate dietary fibre intake Insufficient fluid consumption Reduced physical activity levels Concurrent medications with constipating effects (such as opioids, certain antidepressants, or iron supplements) Older age , where baseline colonic motility may already be reduced The severity of constipation often correlates with the dose of medication and may be more pronounced during dose escalation phases

Insurers should consider the impact on business, including pricing and reserving assumptions, new policyholder behaviors, underwriting, and claims

It helped restore normal sleep architecture, a critical distinction from pharmaceutical sleep aids that often suppress certain sleep stages while artificially extending others

Application of encapsulation strategies for probiotics: from individual loading to co-encapsulation