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This thought led to the development of the group of drugs known as GLP-1 receptor agonists

Over a 48-week trial in adults with obesity but no diabetes, the highest tested dose of 12 mg once weekly produced an average 24.2% reduction in body weight , compared with just over 2% in the placebo group

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All age groups in the clinical trial (18-65) showed meaningful weight loss exceeding 20% at the 12mg dose