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The use of humanized mice was required, as it is well-established that human albumin binds poorly to mouse FcRn 13,70,71,72,73

Botox is important in aesthetic medicine because it offers a safe, FDA-approved treatment option with a well-documented history of efficacy and safety, supported by numerous clinical studies demonstrating its effectiveness in muscle relaxation and wrinkle reduction (see FDA Botox Approval)

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