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1 Introduction HF, the terminal stage of several cardiovascular diseases, affects over 64 million individuals globally, despite a decline in the incidence growth rate due to medical advancements (Savarese et al., 2023)

Surprisingly, another study showed that diabetes-related cardiovascular autonomic damage is first manifested in the vagus nerve (106), which may involve a ferroptosis-mediated overall decrease in parasympathetic tone, ultimately leading to over-activation of the sympathetic nerve and the worsening development of metabolic complications