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A 12-week randomized, double-blind, placebo-controlled study found that a combination of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 effectively reduced inflammation and alleviated psychiatric symptoms in patients with Major Depressive Disorder (MDD) who were on a gluten-free diet [89]

On the other hand, the control group exhibited no significant changes (106.4 27.2 vs