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In model experiments in pigs, they demonstrated that it was possible to completely protect infused GLP-1 against DPP-4 mediated degradation, and that this protection resulted in marked increase in the insulin response to glucose and GLP-1 (102)

Maximal Mitochondrial Respiration and Reserve Capacity are induced after Prolonged GLP-1R Activation Extracellular flux analysis can be used to assess mitochondrial bioenergetics through measurements of oxygen consumption rates (OCR) following the injection of specific mitochondrial inhibitors 24